DIC CAS 693-13-0 N,N’-Diisopropylcarbodiimide Coupling Reagent Purity >99.0% (GC) Factory

N,N'-Diisopropylcarbodiimide (DIC) (CAS: 693-13-0), a carbodiimide compound having an isopropyl substituent on both nitrogen atoms. DIC is colorless to light yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether. DIC can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is very toxic and caused contact dermatitis in a laboratory worker.
DIC is a coupling reagent for peptide synthesis. DIC is an alternative to dicyclohexylcarbodiimide in peptide synthesis. Used in peptide coupling, amino acid, protein synthesis. DIC can be used as a condensation dehydrating agent and dehydrosulfide agent in organic synthesis and pharmaceutical synthesis. Compared with N,N-dicyclohexylcarbodiimide, it has obvious advantages. It not only has extremely strong dehydration, but also can be completely removed after the reaction.
DIC is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature. This product can also be used in synthesis of peptide and nucleic acid. It is easy to use this product to react with compound of free carboxy and amino-group into peptide. This product is widely used in medical, health, make-up and biological products, and other synthetic fields.
DIC is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. In addition to this, it is used in the synthesis of acid anhydride, aldehyde, ketone and isocyanate.
DIC is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.
DIC also can be used as: A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively. A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction. A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.