Trimethylsilyl Trifluoromethanesulfonate (TMSOTf) CAS 27607-77-8 Purity >99.0% (GC)

Trimethylsilyl Trifluoromethanesulfonate (TMSOTf) (CAS: 27607-77-8) is a strong Lewis acid catalyst and efficient silylating agent. Usually used in a Dieckmann-like cyclization of ester-imides and diesters,and also used to prepare difluoroboron triflate etherate a powerful Lewis acid especially in acetonitrile solvent. Trimethylsilyl Trifluoromethanesulfonate is generally used following reactions:1. Silylation. TMSOTf is widely used in the conversion of carbonyl compounds to their enol ethers. The conversion is some 109 faster with TMSOTf/triethylamine than with chlorotrimethylsilane. Trimethylsilyl Trifluoromethanesulfonate is used as catalyst and silicon based reagent in organic synthesis
Trimethylsilyl Trifluoromethanesulfonate has been used in combination with boron trifluoride etherate for the copper-catalyzed asymmetric allylic alkylation (AAA) of allyl bromides, chlorides, and ethers with organolithium reagents in the presence of a chiral ligand.
Trimethylsilyl Trifluoromethanesulfonate is a useful reagent in organic synthesis. It is a strong nucleophile which can be used as a catalyst in organic reactions. TMSOTf is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other industrial chemicals. TMSOTf is also used in the synthesis of peptides, peptidomimetics, and other biomolecules. Additionally, it contributes to the synthesis of polymers, dyes, and diverse materials. With its potent nucleophilicity, TMS-TFMS effectively reacts with electrophilic compounds, encompassing alkenes, alkynes, aromatics, and heterocycles. The reagent′s ability to form covalent bonds with electrophiles leads to the creation of novel molecules, further enhancing its utility in organic synthesis.